Clinical profile and pattern of Henoch-Schönlein purpura in children

Abstract

Introductions: This study was done to evaluate clinical profile of Henoch-Schönlein purpure (HSP) in children admitted in Patan Hospital.

 

Methods:  The medical records of all children admitted in children ward with the diagnosis of HSP from January 2008 to December 2015 were analysed for clinical presentation, management and outcome.

 

Results: Of 59 patients, 37(63%) were boys. The patients’ ages ranged from 15 months to 14 years with a mean of 8.3 years. Approximately two third cases presented during winter and autumn. Upper respiratory tract infection preceded HSP in 37 and anti streptolysin O titer was positive in 6 of the 13 (46%) children tested at presentation. Skin purpura was seen in 59 (100%), arthritis or arthralgia 48 (81%), gastrointestinal manifestation 47 (80%) and renal involvement 16 (27%). Forty one (69%) patients received corticosteroid therapy. All children made a full recovery, two with nephritis continued to have hypertension, hematuria and proteinuria. Symptoms occurred in 6 (10%) over a period one month to two years follow up.

 

Conclusion: The HSP in children had seasonal occurrence, skin rash, pain abdomen with mild disease and recovered well.

 

Key Words:  clinical profile, Henoch-Schönlein purpura, vasculitis, palpable purpura