Correlation of ultrasound imaging with histopathological findings in gestational trophoblastic disease

Abstract

Introduction:  Gestational trophoblastic diseases (GTD) include a spectrum of pregnancy-related diseases caused by abnormal proliferation of the placenta .  The main aim of this study to study the Correlation of ultrasound imaging with histopathological findings in gestational trophoblastic disease.

Method: This is the retrospective study consisting of 155 sonographically diagnosed cases of GTD collected for three years 2016-2019. These patients were evaluated by transabdominal sonography. All these patients underwent Evacuation of product of conception (POC) and samples were subsequently sent for histopathological examination Their histopathological reports were followed up. The Correlation between USG and histopathological findings in GTD was studied.

Result :  Among these 155 sonographically diagnosed cases of GTD 141 (91.0%) were  histologically confirmed GTD,  14 (9.0%) were  non-molar miscarriages on histological examination. In 141 cases of histologically confirmed GTD, 110 (71.0 %) were partial mole, 15 (9.7%) complete mole, 12 (7.7%) invasive mole and 3 (1.9 %) persistent mole, 1(0.6%) was choriocarcinoma.

Conclusion :  The diagnostic accuracy of ultrasound to be 90% in the diagnosis of GTD, increasing its reliability. Thus ultrasound seems to be an initial modality of choice in the workup of every woman suspected of having GTD.