Outcome of COVID-19 Infection in vaccinated and unvaccinated adults admitted to Patan Hospital, Nepal

COVID-19 outcome in vaccinated and unvaccinated

Authors

Keywords:

COVID-19, Covishield, Disease Severity, Disposition, Mortality, Outcome, Unvaccinated, Vaccinated, Vero Cell

Abstract

Introduction: The vaccine has a positive impact on reducing the severity of the COVID-19 disease course and studies have projected 50-90% protection against severe disease. Our study aimed to find the difference in disease severity outcomes between RT-PCR positive vaccinated and unvaccinated individuals.

Method: This cross-sectional study was carried out among 417 COVID-19 cases who were admitted from June 2021 to August 2021. Collected data were fed into Microsoft-excel and analyzed using SPSS software, version- 16.0. Frequency, percentage, mean and standard deviation were calculated for descriptive analysis. To find out the association of categorical variables, the Chi-square test or Fisher’s Exact test was used where appropriate. P-value <0.05 was considered significant.

Result: Out of 417 cases, 23(5.5%) were fully vaccinated i.e. 10(2.4%) with Covishield and 13(3.1%) with Vero Cell, 48(11.5%) partially vaccinated i.e. 19(4.6%) with Covishield, and 29 (6.9%) with Vero Cell and 346(83%) unvaccinated. 343(82.25%) admitted patients were discharged and 74(17.75%) died during our study period. The disposition of the patient was statistically significant (p<0.001) and revealed more mortality among unvaccinated cases. There was a statistical difference between the requirement of ICU admission (p=0.032) among vaccinated and unvaccinated cases. The Absolute Risk Reduction (ARR) of mortality and requirement of ICU after complete vaccination with respect to unvaccinated COVID-19 patients was 14.11%(5.14%-23.73%) and 20.50%(8.02%-32.97%) respectively at 95% CI.

Conclusion: Vaccination reduces Mortality, the requirement of ICU, and oxygen requirement among COVID-19 cases with respect to unvaccinated COVID-19 cases.

Author Biographies

John Shrestha, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Medical Officer, Department of General Practice and Emergency Medicine, Patan Hospital

Mukesh Kumar Sah, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal

Resident, Department of General Practice and Emergency Medicine, Patan Hospital

Bishnu Mohan Singh, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Medical Officer, Department of General Practice and Emergency Medicine, Patan Hospital

Nishan Upreti, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Medical Officer, Department of Internal Medicine, Patan Hospital

Sujina Maskey, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Medical Officer, Department of General Practice and Emergency Medicine, Patan Hospital

Ashish Jha, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Resident, Department of Internal Medicine, Patan Hospital

Bibek Dhital, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Medical Officer, Department of General Practice and Emergency Medicine, Patan Hospital

Bandej Rana, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Medical Officer, Department of Internal Medicine, Patan Hospital

Bimal Pandey, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Assistant Professor, Department of Internal Medicine, Patan Hospital

Ashis Shrestha, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Assistant Professor, Department of General Practice and Emergency Medicine, Patan Hospital

https://doi.org/10.3126/jpahs.v9i2.49042

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Published

2022-11-06

Issue

Section

COVID-19: General Original

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