Histopathological findings of renal biopsy in systemic lupus erythematousus

Sanjit Karki, Roshan Shrestha, Buddhi Poudyal, Bimal Pandey, Nora Ranjitkar, Yubaraj Sharma, Gyan Krishna Kayastha

Abstract


Introductions: Classifying morphological pattern of renal involvement is important in systemic lupus erythematosus (SLE) for definitive treatment and prognosis. This study aim to analyse the histopathological pattern of glomerular in SLE patients.

Methods: This was a retrospective chart review of patients diagnosed with SLE who had renal biopsy during October 2013 to September 2015 at Patan Hospital.

Results: There were 38 patients of SLE.  Antinuclear antibody (ANA) was positive in all patients 38 (100 %), Anti-dsDNA seen in 18 (47.4%). Active urinary sediment & proteinuria was seen 25 (65.8%) patients and proteinuria in 13 (34.2%) patients. Histopathological patterns were of glomerular involvement was, ISN Class II in 2 (5.3%), Class III in 2 (5.3%), class IV 20 (52.5%), class V in 6 (15.8%) and mixed IV –V in 8 (21.1%).

Conclusions: The diffuse proliferative lupus nephritis (ISN Class IV) was the most com­mon pattern of lupus nephritis encountered in our study followed by mixed pattern (ISN class IV&V) and membranous lupus nephritis (ISN class IV).


Keywords
: histopathology, lupus nephritis, renal biopsy, systemic lupus erythematosus


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