Misoprostol for Termination of Second Trimester Pregnancy

  • Sarda Duwal Shrestha Patan Academy of Health Sciences, Lalitpur, Nepal
  • Alka Singh Patan Academy of Health Sciences, Lalitpur, Nepal
  • Laxmi RC Patan Academy of Health Sciences, Lalitpur, Nepal
  • Binita Pradhan Patan Academy of Health Sciences, Lalitpur, Nepal
  • WuFei Shah Patan Academy of Health Sciences, Lalitpur, Nepal
  • Reena Shrestha Patan Academy of Health Sciences, Lalitpur, Nepal

Abstract

Introductions: The termination of second trimester pregnancy is challenging due unfavorable cervix. This study evaluate the efficacy and maternal side effects of intravaginal misoprostol for termination of second trimester pregnancy.
Methods: During one year period from 15th June 2011 to 14th June 2012,
Department of Obstetrics and Gynaecology of Patan Hospital, women admitted for second trimester termination of pregnancy for fetal congenital anomalies and intrauterine fetal demise were studied using the International Federation of Gynaecology and Obstetrics recommended doses of vaginal misoprostol. For congenital anomalies, 400 mcg 3 hourly to a maximum of 5 doses were used. For fetal demise, gestational age of 13-17 weeks received 200 mcg every 6 hourly to a maximum of 4 doses, and 18-26 weeks dose was adjusted to 100 mcg. Main outcome measures included success rate of abortion within 48 hours, induction to delivery interval and maternal side effects.
Results: There were 40 patients during study period. Success rate for termination of 2nd trimester pregnancy within 48 hours was 88.8% for congenital anomalies. For fetal demise, success of termination was 90.9% at 13-17 weeks and 100% at 18-26 weeks. Median time from induction to delivery was 26.8 hours for congenital anomalies. For fetal demise, it was 18 hours for 13-17 weeks was and 24 hours at 18 to 26 weeks respectively. Abdominal pain was seen in all doses of misoprostol.
Conclusions: Vaginal misoprostol is an effective method for termination of
second trimester pregnancy.
Keywords: misoprostol, pregnancy, second trimester termination

Author Biographies

Sarda Duwal Shrestha, Patan Academy of Health Sciences, Lalitpur, Nepal
Lecturer, Department of Obstetrics and Gynecology, Patan Academy of Health Sciences, Lalitpur, Nepal
Alka Singh, Patan Academy of Health Sciences, Lalitpur, Nepal
Associate Professor, Department of Obstetrics and Gynecology, Patan Academy of Health Sciences, Lalitpur, Nepal
Laxmi RC, Patan Academy of Health Sciences, Lalitpur, Nepal
Senior Registrar, Department of Obstetrics and Gynecology, Patan Academy of Health Sciences, Lalitpur, Nepal
Binita Pradhan, Patan Academy of Health Sciences, Lalitpur, Nepal
Lecturer, Department of Obstetrics and Gynecology, Patan Academy of Health Sciences, Lalitpur, Nepal
WuFei Shah, Patan Academy of Health Sciences, Lalitpur, Nepal
Lecturer, Department of Obstetrics and Gynecology, Patan Academy of Health Sciences, Lalitpur, Nepl
Reena Shrestha, Patan Academy of Health Sciences, Lalitpur, Nepal
Lecturer, Department of Obstetrics and Gynecology, Patan Academy of Health Sciences, Lalitpur, Nepal
Published
2014-07-04
Section
General Section - Original Articles